# online education system

Rh system: anti-Cw » Authors: Danielle Meunier, MD; Sophia Peng, MD; and Gwen Clarke, MD, FRCPCPublication date: September 2019Primary target audiences: Medical laboratory technologists (MLT) in a hospital laboratory, transfusion medicine physicians Key points Anti-Cw may be clinically significant. Patients with anti-Cw should receive red blood cell units crossmatch compatible by IAT at 37°C for transfusion. Patients with sickle cell disease who have anti-Cw should be provided with Cw-negative red blood cell units for transfusion. Background Cw (RH8) is one of 54 antigens in the complex Rhesus (Rh) blood group system. The Rh antigens are located on large, multi-looped glycoprotein products of two closely linked genes. Cw is a relatively low-frequency antigen, occurring at an estimated 2% in the general Caucasian population, and up to 7–9% in the Latvian, Laplander and Finnish populations. Its antithetical antigens include CX (RH9, an abnormal Cw) and the high-incidence MAR (RH51) antigen. Due to the location of Cw on the RHCE Professionaleducation.blood.ca

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Red Hat System Administration I | RH124 » Red Hat System Administration I (RH124) develops the core administration skills needed for the management of Red Hat Enterprise Linux servers. Redhat.com

Rh System: Anti-V » Authors: Danielle Meunier, MD; Sophia Peng, MD; and Gwen Clarke, MD, FRCPC Publication date: September 2019 Primary target audiences: Medical laboratory technologists (MLT) in a hospital laboratory, transfusion medicine physicians Key points Anti-V is not clinically significant. Patients with anti-V should receive V-negative donor red blood cells that are crossmatch compatible by IAT at 37°C for transfusion. Sickle cell patients with anti-V should be provided with V-negative red blood cell units for transfusion. Background V (RH10) is one of 54 antigens in the complex Rhesus (Rh) blood group system. V, like the commonly recognized Rh antigens C, c, E, e, is located on a large, multi-looped glycoprotein product of the RHCE gene. V is rare in the Caucasian population, occurring at an estimated 1%, but is very common in people of African descent, occurring at an estimated 30%. Though not an antithetical pair, V antigen is associated with the VS antigen; both are thought to be “uncovered” by a mutation in th Professionaleducation.blood.ca